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Good point! A cast bullet does get re-sized a bit on it's trip down the barrel, especially from revolvers.
So, let's restate the question another way: Given that the bullet won't leave the barrel in exactly the same condition it left the cartridge case, what are the important attributes of the bullet that must be kept?
Let's start with the bullet base. It needs to start out uniform and leave the barrel in a uniform state (minus the groves that the rifling will put into it). If it is damaged on one side, the powder gases will tip the base as it leaves the bore, reducing downrange accuracy.
So that's the reason for holding the sizing tolerances just so. When the bullet leaves the case, we don't want powder gases to escape past it, which would likely start to erode the edges of the base. Therefore size so it will just fit in the throats. It needs to be round, of course.
Then, if the throats are just a bit bigger than the rifling, the gas seal will hold when the bullet jumps into the barrel. If the groove diameter of the rifling is larger than the cylinder throats, then it is unlikely that this gun will shoot cast bullets well, althought sometimes gas checks help a little.
Other attributes... weight. A uniform weight, combined with a good gas seal and uniform powder charges, should help deliver a uniform velocity which will help downrange accuracy. Non-uniform weights often indicate voids in the bullet's interior, which could throw the bullet out of balance and that's not good.
As far as the rest goes.... probably some things are not as critical as we'd imagine. Bullet appearance kind of helps us judge what the casting temperature is and whether the bullet filled out OK, but isn't a critical indicator by itself. The nose of the bullet is about the least critical part, assuming it's not severely damaged.
Hope this helps.
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